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概述EoE發病機理(改編自文獻[59])。Bas、嗜堿粒細胞;Eos,嗜酸性粒細胞;IL,白介素;iLC2,先天淋巴細胞2型;iNKT,不變的自然殺傷T細胞;桅杆,肥大細胞;Th,輔助T細胞。過敏原刺激食管上皮細胞誘導TSLP,導致刺激Th2細胞,NK細胞,肥大細胞,嗜堿粒細胞,iLC2。這些細胞產生il - 4促進Th2分化。 IL-4 and IL-13 induced by Th2 cells induce eotaxin-3 (CCL26), which stimulates eosinophils to secrete IL-5. IL-5, secreted by Th2 cells and mast cells, stimulate eosinophils as well. Mast cells also induce TGF-b1 which stimulate eosinophils and fibroblasts. Furthermore, IL-13 induces impaired barrier function and tissue remodeling